Age-Related Heterologous Antibody Responses to Influenza Virus Vaccination
Identifieur interne : 002A78 ( Main/Exploration ); précédent : 002A77; suivant : 002A79Age-Related Heterologous Antibody Responses to Influenza Virus Vaccination
Auteurs : Gary R. Noble [Géorgie (pays), États-Unis] ; Harold S. Kaye [Géorgie (pays)] ; Alan P. Kendal [Géorgie (pays)] ; Walter R. Dowdle [Géorgie (pays)]Source :
- Journal of Infectious Diseases [ 0022-1899 ] ; 1977.
Descripteurs français
- KwdFr :
- MESH :
- biosynthèse : Anticorps antiviraux.
- immunologie : Virus de la grippe A.
- pharmacologie : Vaccins antigrippaux.
- Adolescent, Adulte, Adulte d'âge moyen, Angleterre, Facteurs temps, Humains, New Jersey, Vaccination, Vieillissement.
English descriptors
- KwdEn :
- MESH :
- chemical , biosynthesis : Antibodies, Viral.
- chemical , pharmacology : Influenza Vaccines.
- geographic : England, New Jersey.
- immunology : Influenza A virus.
- Adolescent, Adult, Aging, Humans, Middle Aged, Time Factors, Vaccination.
Abstract
Heterologous hemagglutination-inhibiting (HAI) antibody responses to influenza A/New Jersey/76 (Hsw1Nl) virus vaccine were examined in individuals receiving doses of 200, 400, or 800 chick cell-agglutinating units of whole-virus or split-virus products during the 1976 National Influenza Vaccine Test Program. Vaccination with influenza A/New Jersey/76 virus produced a high rate or heterologous antibody response to influenza A/PR/8/34 (H0N1) and A/FM/l/47 (HIN1) viruses in persons whose original antigenic experience according to their age was with H0N1 or H1N1 strains, respectively. Vaccination with A/New jersey/76 virus produced only low levels of HA1 antibody to influenza A/Japan/305/57 (H2N2) and A/Victoria/3/75 (H3N2) viruses, and these responses were less clearly related to primary infections. Thus the greatest heterologous HA1 antibody responses occurred when there were shared antigenic determinants between the hemagglutinins of the vaccine virus and the viruses that had caused the initial priming infection. However, when vaccinations or infections with H3N2 and HswlNI strains may both be occurring in the population, even infrequent formation of heterologous antibody may make it difficult to interpret serologic data precisely.
Url:
DOI: 10.1093/infdis/136.Supplement_3.S686
Affiliations:
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Noble</name><affiliation wicri:level="1"><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>World Health Organization Collaborating Center for Influenza, Respiratory Virology Branch, Virology Division, Bureau of Laboratories, Center for Disease Control, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName><wicri:cityArea>Please address requests for reprints to Dr. Gary R. Noble, Respiratory Virology Branch 7-112, Center for Disease Control, Atlanta</wicri:cityArea></affiliation></author><author><name sortKey="Kaye, Harold S" sort="Kaye, Harold S" uniqKey="Kaye H" first="Harold S." last="Kaye">Harold S. Kaye</name><affiliation wicri:level="1"><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>World Health Organization Collaborating Center for Influenza, Respiratory Virology Branch, Virology Division, Bureau of Laboratories, Center for Disease Control, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author><author><name sortKey="Kendal, Alan P" sort="Kendal, Alan P" uniqKey="Kendal A" first="Alan P." last="Kendal">Alan P. Kendal</name><affiliation wicri:level="1"><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>World Health Organization Collaborating Center for Influenza, Respiratory Virology Branch, Virology Division, Bureau of Laboratories, Center for Disease Control, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author><author><name sortKey="Dowdle, Walter R" sort="Dowdle, Walter R" uniqKey="Dowdle W" first="Walter R." last="Dowdle">Walter R. Dowdle</name><affiliation wicri:level="1"><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>World Health Organization Collaborating Center for Influenza, Respiratory Virology Branch, Virology Division, Bureau of Laboratories, Center for Disease Control, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Infectious Diseases</title><title level="j" type="abbrev">J Infect Dis.</title><idno type="ISSN">0022-1899</idno><idno type="eISSN">1537-6613</idno><imprint><publisher>The University of Chicago Press</publisher><date when="1977-12">1977</date><biblScope unit="vol">136</biblScope><biblScope unit="issue">Supplemet_3</biblScope><biblScope unit="page" from="S686">S686</biblScope><biblScope unit="page" to="S692">S692</biblScope></imprint><idno type="ISSN">0022-1899</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-1899</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aging</term><term>Antibodies, Viral (biosynthesis)</term><term>England</term><term>Humans</term><term>Influenza A virus (immunology)</term><term>Influenza Vaccines (pharmacology)</term><term>Middle Aged</term><term>New Jersey</term><term>Time Factors</term><term>Vaccination</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Angleterre</term><term>Anticorps antiviraux (biosynthèse)</term><term>Facteurs temps</term><term>Humains</term><term>New Jersey</term><term>Vaccination</term><term>Vaccins antigrippaux (pharmacologie)</term><term>Vieillissement</term><term>Virus de la grippe A (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Influenza Vaccines</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>England</term><term>New Jersey</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Anticorps antiviraux</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Vaccins antigrippaux</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aging</term><term>Humans</term><term>Middle Aged</term><term>Time Factors</term><term>Vaccination</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Angleterre</term><term>Facteurs temps</term><term>Humains</term><term>New Jersey</term><term>Vaccination</term><term>Vieillissement</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract">Heterologous hemagglutination-inhibiting (HAI) antibody responses to influenza A/New Jersey/76 (Hsw1Nl) virus vaccine were examined in individuals receiving doses of 200, 400, or 800 chick cell-agglutinating units of whole-virus or split-virus products during the 1976 National Influenza Vaccine Test Program. Vaccination with influenza A/New Jersey/76 virus produced a high rate or heterologous antibody response to influenza A/PR/8/34 (H0N1) and A/FM/l/47 (HIN1) viruses in persons whose original antigenic experience according to their age was with H0N1 or H1N1 strains, respectively. Vaccination with A/New jersey/76 virus produced only low levels of HA1 antibody to influenza A/Japan/305/57 (H2N2) and A/Victoria/3/75 (H3N2) viruses, and these responses were less clearly related to primary infections. Thus the greatest heterologous HA1 antibody responses occurred when there were shared antigenic determinants between the hemagglutinins of the vaccine virus and the viruses that had caused the initial priming infection. However, when vaccinations or infections with H3N2 and HswlNI strains may both be occurring in the population, even infrequent formation of heterologous antibody may make it difficult to interpret serologic data precisely.</div></front></TEI><affiliations><list><country><li>Géorgie (pays)</li><li>États-Unis</li></country><region><li>Géorgie (États-Unis)</li></region></list><tree><country name="Géorgie (pays)"><noRegion><name sortKey="Noble, Gary R" sort="Noble, Gary R" uniqKey="Noble G" first="Gary R." last="Noble">Gary R. Noble</name></noRegion><name sortKey="Dowdle, Walter R" sort="Dowdle, Walter R" uniqKey="Dowdle W" first="Walter R." last="Dowdle">Walter R. Dowdle</name><name sortKey="Kaye, Harold S" sort="Kaye, Harold S" uniqKey="Kaye H" first="Harold S." last="Kaye">Harold S. Kaye</name><name sortKey="Kendal, Alan P" sort="Kendal, Alan P" uniqKey="Kendal A" first="Alan P." last="Kendal">Alan P. Kendal</name></country><country name="États-Unis"><region name="Géorgie (États-Unis)"><name sortKey="Noble, Gary R" sort="Noble, Gary R" uniqKey="Noble G" first="Gary R." last="Noble">Gary R. Noble</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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